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KMID : 1101820130010010015
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Journal of Breast Disease
2013 Volume.1 No. 1 p.15 ~ p.20
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Hazard of Recurrence after Breast Surgery according to Hormone Receptor Status and Age
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Jung Seung-Pil
Woo Sook-Young
Lee Se-Kyung
Kim Sang-Min
Bae Soo-Youn
Kim Ji-Young
Kim Min-Kuk
Kil Won-Ho
Nam Seok-Jin
Lee Jeong-Eon
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Abstract
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Purpose: Breast cancer can recur many years after treatment. Most studies have focused on survival rate and survival curves. We estimated hazard rates for recurrence to evaluate the risk of recurrence at a given time and how to recurrence changes over time according to hormone receptor status and patient age.
Methods: We retrospectively reviewed the medical records of 6,308 patients with stage 1-3 breast cancer who received breast cancer operation from 1995 to 2010. Hazard rates were estimated by using Proc Lifetest. Patients were grouped according to estrogen receptor (ER) status; ER (+, n=4,589), ER (-, n=1,719) and age; less than 39 year (n=1,192), 40-59 year (n=4,250), more than 60 year (n=866).
Results: Median follow up period was 60 months. Estimated 5-year and 10-year recurrence rate were 11.2% and 19.5% in overall cohort. Estimated 5-year and 10-year recurrence rate were 10.6% and 18.4% in ER(+) patients, and 16.6% and 18.4% in ER(-) patients. Hazard of recurrence (HR) was highest in 2-3 years after surgery in overall cohort. ER(-) patients showed steep pattern of HR, while ER(+) patient showed steady pattern of HR. Five years after surgery, HR was higher in ER(+) patients than ER(-) patients. Younger patients showed higher HR than older patients regardless of ER status and stage.
Conclusion: Our study proved that ER(-) patients showed high recurrence rate in early post-operative stage, however, in late post-operative stage, ER(-) patient showed lower recurrence rate than ER(+) patient. Young patients should be carefully observed because of high and long standing hazard of recurrence especially in ER(+) patients.
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KEYWORD
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Age, Breast neoplasms, Estrogen receptor, Recurrence, Survival
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